Bioidentical vs. Synthetic Hormones: Clearing Up the Confusion
Not All Hormones Are Created Equal
One of the most common misunderstandings in menopause care is the belief that all hormones are the same. In reality, there’s a major difference between synthetic hormones and bioidentical ones—and it affects how your body responds to treatment.
The Menopause Association supports a deeper understanding of these options so that women can make safe, informed choices.
What Are Bioidentical Hormones?
Bioidentical hormones are chemically identical to the hormones your body naturally produces. They can be derived from plant sources and are formulated to match your personal hormone levels through compounding or FDA-approved products.
Types include:
- Estradiol (a natural form of estrogen)
- Micronized progesterone
- Testosterone (in small, carefully monitored doses)
What Are Synthetic Hormones?
Synthetic hormones are manufactured in labs and do not exactly match the structure of human hormones. While some are effective for symptom relief, they may carry higher risks for side effects, especially when used long-term or without proper monitoring.
Examples include:
- Medroxyprogesterone acetate
- Conjugated equine estrogens
Key Differences
Factor | Bioidentical | Synthetic |
Matches natural hormones | ✅ Yes | ❌ No |
Customizable dosing | ✅ Often | ❌ Typically not |
FDA-approved options | ✅ Yes | ✅ Yes |
Compounded versions | ✅ Available | ❌ Rare |
So Which Is Better?
There’s no universal answer. The safest and most effective option depends on your body, your symptoms, and your personal risk factors. That’s why individualized care matters.
Learn more about BHRT treatment options or visit our myths page about the WHI study (link to /menopause/myths/whi-study) for additional context.